Selected Publications

Clinical Research
Research on Colon Cancer Angiogenesis
Research in Growth Factors and Metastasis
Research in the Biology of Colon Cancer Metastasis to the Liver
Research in Signal Transduction of Colon Cancer Liver Metastasis

 

 

 

 

 

 

 

 

 

 

 

 

Clinical Research

Abdalla EK, Lauwers GY, Forsmark CE, Vauthey JN. Monolobar Caroli’s disease and cholangiocarcinoma. HPB Surgery 1999; 11: 271-277.

Balch G, Izzo F, Chiao P, Klostergaard J, Curley SA. Thymostimulin (TP-1) activates human Kupffer cells to produce cytotoxicity against human hepatocellular cancer. Ann Surg Oncol 1997; 4:149-155.

Bilimoria MM, Chaoui AS and Vauthey JN. Postoperative Liver Failure J Am Coll Surg 1999: 188(3):304-309.

Cendan JC, Zlotecki RA, Vauthey JN. Biliary Tract Cancer. Curr Op Gastroenterol 1996; 12: 460–465.

Curley SA, Izzo F, Delrio P, Ellis LM, Granchi J, Vallone P, Fiore F, Cremona F. Radiofrequency ablation of unresectable primary and metastatic hepatic malignancies: results in 123 patients. Ann Surg 1999; 230:1-8.

Davidson BS, Izzo F, Chase JL, Patt Y, Hohn DC, Curley SA. Alternating floxuridine and 5-fluorouracil hepatic arterial chemotherapy for colorectal liver metastases minimizes biliary toxicity. Am J Surg 1996; 172:244-247.

Dudrick P, Vauthey JN. Biliary Tract Cancer. Curr Op Gastroenterol 1995; 11: 445–451.

Ehrenfried JA, Vauthey JN. Biliary Tract Cancer. Curr Op Gastroenterol, 1999; 15: 430-435.

Espat NJ, Vauthey JN. Biliary Tract Cancer. Curr Op Gastroenterol, 1997; 13: 410–415.

Freeman ME, Rose JL, Forsmark CE, Vauthey JN. Mirizzi Syndrome: A rare cause of obstructive jaundice. Dig Dis 1999; 17(1): 44-48.

Gertsch Ph, Vauthey JN, Looser C, Triller J, Blumgart LH. Evaluation of adaptive changes by non–invasive imaging in hepatic vein outflow obstruction. HPB Surgery 1995; 8: 231–236.

Han NM, Curley SA, Gallick GE. Differential activation of pp60^c-src and pp62^c-yes in human colorectal carcinoma liver metastases. Clin Cancer Res 1996; 2:1397-1404.

Han NM, Fleming RYD, Curley SA, Gallick GE. Overexpression of focal adhesion kinase is independent of activation of c-Src or c-Yes in human colorectal carcinoma liver metastases. Ann Surg Oncol 1997; 4(3):264-268.

Izzo F, Cremona F, Delrio P, Leonardi E, Castello G, Pignata S, Daniele B, Curley SA. Soluble interleukin-2 receptor levels in hepatocellular cancer: a more sensitive marker than alfa fetoprotein. Ann Surg Oncol 1999; 6(2): 178-185.

Izzo F, Cremona F, Ruffolo F, Palaia R, Parisi V, Curley SA. Outcome of 67 hepatocellular cancer patients detected during screening of 1,125 chronic hepatitis patients. Ann Surg 1998; 227:513-518.

Izzo F, Curley SA, Maio P, Leonardi E, Imparato L, Giglio S, Cremona F, Castello G. Correlation of soluble interleukin-2 receptor levels with severity of chronic hepatitis C virus injury to the liver and development of hepatocellular cancer. Surgery 1996; 120:100-105.

Izzo F, Di Muria A, Ruffolo F, Parisi V, Curley SA. Intraoperative use of radiofrequency interstitial tissue ablation to treat primary and metastatic liver tumors. Gastroenterology International 1997; 10:515-516.

Jones DV, Chase J, Roh M, Hohn DC, Curley SA, Smith R, Hoque A, Patt YZ. A phase I evaluation of chronotropic delivery of floxuridine by hepatic arterial infusion in patients with metastatic colorectal cancer. Oncol Reports 1996; 3:391-395.

Josephs M, Vauthey, JN. Biliary Tract Cancer. Curr Op Gastroenterol. 1998; 14: 402-407.

Kuo MT, Jia-Ju B,Curley SA, Ikeguchi M, Johnston DA, Ishikawa T. Frequent coordinated overexpression of the MRP/GS-X pump and Glutamylcysteine synthetase genes in human colorectal cancers. Cancer Res 1996; 56:3642-3644.

Lauwers, GY, Vauthey JN. Pathological aspects of hepatocellular carcinoma: a critical review of prognostic factors. Hepatogastroenterology 1998; 45: 1197-202.

McMasters KM, Tuttle TM, Leach SD, Rich T, Evans DB, Curley SA. Neoadjuvant chemoradiation enhances margin-negative resection rates for extrahepatic cholangiocarcinoma. Am J Surg 1997; 174:605-609.

Patt YZ, Hoque A, Lozano R, Pazdur R, Chase J, Carrasco H, Chuang V, Delpassand ES, Ellis L, Curley SA, Roh M, Jones, Jr, DV. Phase II trial of hepatic arterial infusion of fluorouracil and recombinant human interferon alfa-2b for liver metastases of colorectal cancer refractory to systemic fluorouracil and leucovorin. J Clin Oncol 1997; 15(4):1432-1438.

Pearlstone DB, Mansfield PF, Curley SA, Kamparatana M, Cook P, Feig BW. Laparoscopy in 533 patients with abdominal malignancy. Surgery 1999; 125(1):67-72.

Ricardo A, Feig BW, Ellis LM, Curley SA , MacFadyen BV, Mansfield PF. Gallbladder cancer and trocar site recurrences: the facts regarding the myth. Am J Surg 1997; 174:619-623.

Tuttle TM, Curley SA, Roh MS. Repeat hepatic resection is effective treatment for recurrent colorectal hepatic metastases. Ann Surg Oncol 1997; 4:125-130.

Vauthey JN, Baer HU, Guastella T, Blumgart LH. Comparison of outcome between extended and non–extended liver resections for neoplasms. Surgery 1993; 114: 968–975.

Vauthey JN, Blumgart LH. Recent advances in the management of cholangiocarcinomas. Semin Liver Dis 1994; 14: 109–114.

Vauthey JN, Dudrick PS, Lind DS, Copeland EM III. Management of recurrent colorectal cancer: another look at carcinoembryonic antigen–detected recurrence. Dig Dis 1996; 14: 5–13.

Vauthey JN, Klimstra D, Blumgart LH. A simplified staging system for hepatocellular carcinoma. Gastroenterology 1995; 108: 617–618.

Vauthey JN, Klimstra D, Franceschi D, Tao Y, Fortner JG, Blumgart LH, Brennan MF. Factors affecting long–term outcome after hepatic resection for hepatocellular carcinoma. Am J Surg 1995; 169: 28–35.

Vauthey JN, Lerut J, Martini M, Becker C, Gertsch Ph, Blumgart LH. Indications and limitations of percutaneous cholecystostomy for acute cholecystitis. Surg Gynecol Obstet 1993; 176: 49–54.

Vauthey JN, Maddern GJ, Blumgart LH. Adult polycystic disease of the liver. Br J Surg 1991; 78: 524–527.

Vauthey JN, Maddern GJ, Kolbinger P, Baer HU, Blumgart LH. Clinical experience with adult polycystic liver disease. Br J Surg 1992; 79: 562–565.

Vauthey JN, Marsh RdeW, Cendan JC, Chu NM, Copeland EM III. Arterial therapy of hepatic colorectal metastases. Br J Surg 1996; 83: 447–455.

Vauthey JN, Marsh RdeW, Davis GL. Treatment of unresectable hepatocellular carcinoma. N Engl J Med 1995; 333: 877.

Vauthey JN, Tomczak RJ, Helmberger T, Gertsch P, Forsmark C, Caridi J, Reed A, Langham MR, Lauwers GY, Goffette P, Lerut J. The arterioportal fistula syndrome: clinicopathologic features, diagnosis and therapy. Gastroenterology, 1997; 113: 1390–1401.

Vauthey JN, Winter MW, Blumgart LH. Solitary metastasis from cutaneous melanoma to the liver: resection by extended left hepatectomy (trisegmentectomy) with clearance of tumor from the portal vein. HPB Surgery 1994; 8: 53–56.

Vauthey JN. Liver imaging: a surgeon’s perspective. Radiol Clin N Am 1998; 36(2): 445-457.

Zlotecki RA, Jung LA, Vauthey JN, Vogel SB, Mendenhall WM. Carcinoma of the extrahepatic biliary tract: surgery and radiotherapy for curative and palliative intent. Radiat Oncol Investig 1998; 6: 240-247.

back to index

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 Research on Colon Cancer Angiogenesis

Shaheen, R.M., Liu, W., Davis, D.W., Wilson, M.R., McMahon, J., McConkey, D.J., Ellis, L.M. A Tyrosine Kinase Inhibitor to the Vascular Endothelial Growth Factor Receptor Inhibits Angiogenesis and Growth of Colon Cancer Liver Metastases. Surgical Forum. In Press, 1999.

Zebrowski, B.K., Liu, W., Ramirez, K., Akagi, Y., Mills, G., Ellis, L.M. Markedly Elevated Levels of Vascular Endothelial Growth Factor in Malignant Ascites. Annals of Surgical Oncology, 6(4):373-378, 1999.

Akagi, Y. Liu, W., Zebrowski, B. Xie, K., Ellis, L.M. Regulation of Vascular Endothelial Growth Factor in Human Colon Cancer by Insulin-like Growth Factor-I. Cancer Res, 58:4008-4014, 1998.

Akagi, Y., Liu, W., Xie, K., Zebrowski, B., Shaheen, R.M., Ellis, L.M.: Regulation of Vascular Endothelial Growth Factor Expression in Human Colon Cancer by Interleukin-1 Beta. British Journal of Cancer, In Press, 1999.

Ellis, L.M., Staley, C.A., Liu, W., Fleming, R.Y.D., Parikh, N.U., Bucana, C.D., Gallick, G.E. Down-regulation of vascular endothelial growth factor in a human colon carcinoma cell line transfected with an antisense expression vector specific for c-src. J. Biol. Chem., 273(2):1052-1057, 1998.

Takahashi, Y., Bucana, C.D., Cleary, K.R., Ellis, L.M. p53 vessel count, and vascular endothelial growth factor expression in human colon cancer. Int. J. Cancer, 79, 34-38, 1998.

Takahashi, Y., Kitadai, Y., Bucana, C., Cleary, K.R., Ellis, L.M. Expression of vascular endothelial growth factor and its receptor (KDR) correlates with vascularity, metastasis and proliferation of human colon cancer. Cancer Res., 55:3964-3968, 1995.

Takahashi, Y., Tucker, S.L., Kitadai, Y., Koura, A.N., Bucana, C.D., Cleary, K.R., Ellis, L.M. Vessel counts and expression of vascular endothelial growth factor as prognostic factors in node-negative colon cancer. Arch. Surg., 132:541-546, 1997.

Portera, C.A., Berman, R.S., Ellis, L.M., Molecular determinants of colon cancer metastasis. Surgical Oncology. In Press, 1999.

Fidler, I.J., Kumar, R., Bielenberg, D.R., Ellis, L.M. Molecular determinants of angiogenesis in cancer metastasis. The Cancer J Sc Am., 4(Suppl 1):S58-S66, 1998.

Ellis, L.M., Walker, R.A., Gasparini, G. Is determination of angiogenic activity in human tumours clinically useful? European Journal of Cancer 34:5:609-618, 1998.

Ellis, L.M., Fidler, I.J. Angiogenesis and metastasis. Eur. J. Cancer, 32A(14):2451-2460, 1996.

Radinsky, R., Ellis, L.M. Molecular determinants in the biology of liver metastasis. Surg. Onc. Clin. North Am., 5:215-229, 1996.

Ellis, L.M., Radinsky, R., Fidler, I.J. Recent advances in the biology of cancer invasion and metastasis. In: Bland (ed.), Surgical Oncology: Contemporary Principles and Practice. Appleton and Lange Publishers, Inc. In Press, 1999.

back to index

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Research in Growth Factors and Metastasis

Radinsky, R. Growth factors and their receptors in metastasis. Semin. Cancer Biol., 2:169-177, 1991.

Radinsky, R., Weisberg, H.Z., Staroselsky, A.N., Fidler, I.J. Expression level of the NM23 gene in clonal populations of metastatic murine and human neoplasms. Cancer Res. (Adv. in Brief), 52:5808-5814, 1992.

Radinsky, R., and Fidler, I.J. Growth regulation at organ-specific metastases. In Vivo, 6:325-332, 1992.

Radinsky, R., Bucana, C.D., Ellis, L.M., Sanchez, R., Cleary, K.R., Brigati, D.J., Fidler, I.J. A rapid colorimetric in situ mRNA hybridization technique for analysis of epidermal growth factor receptor in paraffin-embedded surgical specimens of human colon carcinomas. Cancer Res. (Adv. in Brief), 53:937-943, 1993.

Bucana, C.D., Radinsky, R., Dong, Z., Sanchez, R., Brigati, D., and Fidler, I.J. A rapid colorimetric in situ mRNA hybridization technique using hyperbiotinylated oligonucleotide probes for analysis of mouse mdr 1 in colon carcinoma cells. J. Histochem. Cytochem. (Rapid Publication), 41:499-506, 1993.

Radinsky, R. Paracrine growth influences of human colon carcinoma metastasis. Cancer Metastasis Rev., 12:345-361, 1993.

Dong, Z., Radinsky, R., Fan, D., Tsan, R., Bucana, C.D., Wilmanns, C., Fidler, I.J. Organ-specific modulation of steady-state mdr-1 gene expression and drug resistance in murine colon cancer cells. J. Natl. Cancer Inst. 86:913-920, 1994.

Radinsky, R., Risin, S., Fan, D., Dong, Z., Bielenberg, D., Bucana, C.D., and Fidler, I.J. Level and function of epidermal growth factor receptor predict the metastatic potential of human colon carcinoma cells. Clinical Cancer Res., 1:19-31, 1995.

Radinsky, R. Modulation of Tumor Cell Gene Expression and Phenotype by the Organ-Specific Metastatic Environment. Cancer and Metastasis Reviews 14:323-338, 1995.

Kitadai, Y., Radinsky, R., Bucana, C.D., Takahahi, Y., Xie, K., Tahara, E., Fidler, I.J. Regulation of CEA Expression in Human Colon Carcinoma Cells by the Organ Microenvironment. Am. J. Pathol. 149:1157-1166, 1996.

Fidler, I.J. Radinsky, R. Editorial: The Search for Genes that Suppress Cancer Metastasis. J. Nat. Cancer Inst. 88:1700-1703, 1996.

Singh, R. K., Tsan, R., Radinsky, R. Influence of the Host Microenvironment on the Clonal Selection of Human Colon Carcinoma Cells During Primary Tumor Growth and Metastasis. Clin. Expt. Metastasis. 15:140-150, 1997.

Parker, C., Roseman, B.J., Bucana, C.D., Tsan, R., Radinsky, R. Preferential Activation of Epidermal Growth Factor Receptor in the Human Colon Carcinoma Liver Metastases Growing in Nude Mice. J. Histochem and Cytochem., 46:595-602, 1998.

back to index

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Research in the Biology of Colon Cancer Metastasis to the Liver

Kitadai Y, Ellis LM, Takahashi Y, Bucana CD, Anzai H, Tahara E, Fidler IJ. Multi-parametric in situ messenger RNA hybridization analysis to detect metastasis-related genes in surgical specimens of human colon carcinomas. Clin Cancer Res Oct; 1(10):1095-102, 1995.

Shinohara H, Killion JJ, Kuniyasu H, Kumar R, Fidler IJ. Prevention of intestinal toxic effects and intensification of irinotecan's therapeutic efficacy against murine colon cancer liver metastases by oral administration of the lipopeptide JBT 3002. Clin Cancer Res Sep;4(9):2053-63, 1998.

Kitadai Y, Ellis LM, Tucker SL, Greene GF, Bucana CD, Cleary KR, Takahashi Y, Tahara E, Fidler IJ Multiparametric in situ mRNA hybridization analysis to predict disease recurrence in patients with colon carcinoma. Am J Pathol Nov;149(5):1541-51, 1996.

Kitadai Y, Radinsky R, Bucana CD, Takahashi Y, Xie K, Tahara E, Fidler IJ Regulation of carcinoembryonic antigen expression in human colon carcinoma cells by the organ microenvironment. Am J Pathol Oct;149(4):1157-66, 1996.

Takahashi Y, Ellis LM, Wilson MR, Bucana CD, Kitadai Y, Fidler IJ. Progressive upregulation of metastasis-related genes in human colon cancer cells implanted into the cecum of nude mice.  Oncol Res;8(4):163-9, 1996.

Gutman M, Fidler IJ Biology of human colon cancer metastasis. World J Surg Mar-Apr;19(2):226-34, 1995.

Gutman M, Singh RK, Price JE, Fan D, Fidler IJ Accelerated growth of human colon cancer cells in nude mice undergoing liver regeneration. Invasion Metastasis; 14(1-6):362-71, 1995-95.

Fabra A, Nakajima M, Bucana CD, Fidler IJ. Modulation of the invasive phenotype of human colon carcinoma cells by organ specific fibroblasts of nude mice. Differentiation Dec;52(1):101-10, 1992.

Wilmanns C, Fan D, O'Brian CA, Bucana CD, Fidler IJ Orthotopic and ectopic organ environments differentially influence the sensitivity of murine colon carcinoma cells to doxorubicin and 5-fluorouracil. Int J Cancer 1992 Aug 19;52(1):98-104 Cancer Metastasis Rev Oct;10(3):229-43, 1991.

Fidler IJ Orthotopic implantation of human colon carcinomas into nude mice provides a valuable model for the biology and therapy of metastasis. J Natl Cancer Inst Dec 19;82(24):1890-8, 1990.

Nakajima M, Morikawa K, Fabra A, Bucana CD, Fidler IJ Influence of organ environment on extracellular matrix degradative activity and metastasis of human colon carcinoma cells. J Natl Cancer Inst Mar 21;82(6):517-22, 1990.

Morikawa K, Morikawa R, Killion JJ, Fan D, Fidler IJ Isolation of human colon carcinoma cells for resistance to a single interferon associated with cross-resistance to multiple recombinant interferons: alpha, beta, and gamma

Jessup JM, Giavazzi R, Campbell D, Cleary KR, Morikawa K, Hostetter R, Atkinson EN, Fidler IJ Metastatic potential of human colorectal carcinomas implanted into nude mice: prediction of clinical outcome in patients operated upon for cure. Cancer Res Dec 15;49(24 Pt 1):6906-10, 1989.

Schackert HK, Fidler IJ Development of an animal model to study the biology of recurrent colorectal cancer originating from mesenteric lymph system metastases. Int J Cancer Jul 15;44(1):177-81, 1989.

Morikawa K, Fidler IJ Heterogeneous response of human colon cancer cells to the cytostatic and cytotoxic effects of recombinant human cytokines: interferon-alpha,

interferon-gamma, tumor necrosis factor, and interleukin-1. J Biol Response Mod Apr;8(2):206-18, 1989.

Morikawa K, Fan D, Denkins YM, Levin B, Gutterman JU, Walker SM, Fidler IJ Mechanisms of combined effects of gamma-interferon and 5-fluorouracil on human colon cancers implanted into nude mice. Cancer Res Feb 15;49(4):799-805, 1989.

back to index

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Research in Signal Transduction of Colon Cancer Liver Metastasis

Han NM, Curley SA, Gallick GE Differential activation of pp60(c-src) and pp62(c-yes) in human colorectal carcinoma liver metastases. Clin Cancer Res Aug;2(8):1397-404, 1996.

Han NM, Fleming RY, Curley SA, Gallick GE Overexpression of focal adhesion kinase (p125FAK) in human colorectal carcinoma liver metastases: independence from c-src or c-yes activation. Ann Surg Oncol Apr-May;4(3):264-8, 1997.

Staley CA, Parikh NU, Gallick GE Decreased tumorigenicity of a human colon adenocarcinoma cell line by an antisense expression vector specific for c-Src. Cell Growth Differ Mar;8(3):269-74, 1997.

Termuhlen PM, Curley SA, Talamonti MS, Saboorian MH, Gallick GE Site-specific differences in pp60c-src activity in human colorectal metastases. J Surg Res Apr;54(4):293-8, 1993.

Talamonti MS, Roh MS, Curley SA, Gallick GE Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer. J Clin Invest Jan;91(1):53-60, 1993.

Jessup JM, Gallick GE The biology of colorectal carcinoma. Curr Probl Cancer Sep-Oct;16(5):261-328, 1992.

Novotny-Smith CL, Gallick GE Growth inhibition of human colorectal carcinoma cell lines by tumor necrosis factor-alpha correlates with reduced activity of pp60c-src. J Immunother Apr;11(3):159-68, 1992.

Garcia R, Parikh NU, Saya H, Gallick GE Effect of herbimycin A on growth and pp60c-src activity in human colon tumor cell lines. Oncogene Nov;6(11):1983-9, 1991.

Gallick GE, Kurzrock R, Kloetzer WS, Arlinghaus RB, Gutterman JU Expression of p21ras in fresh primary and metastatic human colorectal tumors. Proc Natl Acad Sci U S A Mar;82(6):1795-9, 1985.

 

Back to Top